It could be a big day for Nicky Henderson at Newcastle on Saturday, with his two most high-profile horses, Constitution Hill and Shishkin, entered on the card.

Constitution Hill is one of six left in the BetMGM Fighting Fifth Hurdle while Shishkin, who blotted his copybook by refusing to race at Ascot on Saturday, has been given an entry in the BetMGM Rehearsal Chase.

Not surprisingly, there are not many connections with a smart two-mile hurdler on their hands keen to take on Constitution Hill.

Since his racecourse debut in December 2021, the closest any horse has managed to get to Constitution Hill is three lengths, on his most recent outing at Aintree, where he beat multiple Grade One winner Sharjah.

That followed a nine-lengths stroll in the Champion Hurdle over State Man, another Willie Mullins inmate with a list of successes at the highest level to his name.

There had earlier been wide-margin wins over his stablemate Epatante in both the Christmas Hurdle and this corresponding race last year – and she herself was a previous winner of the Champion Hurdle.

So far, he has not looked like being beaten and he will be a very short price at the weekend to maintain his unblemished record.

There is a previous winner of the Fighting Fifth among his likely opponents in the shape of Hughie Morrison's veteran Not So Sleepy.

He dead-heated with Epatante in 2021 and was last seen running a good race to be seventh in the Cesarewitch.

Shishkin refused to race at Ascot last Saturday

There are two classy mares among his potential opponents, both having won the Dawn Run Mares’ Novices’ Hurdle at the Cheltenham Festival.

Harry Fry’s Love Envoi took the spoils in 2022 and was narrowly beaten by Honeysuckle back at Cheltenham in March, while Jamie Snowden’s You Wear It Well followed in her hoofprints last season.

You Wear It Well reappeared with a good win at Wetherby and is clearly on the up.

Snowden told Sky Sports Racing: "If you’re not in, you can’t run. Constitution Hill has obviously put a few people off.

"We’ve confirmed this morning, we’ll see what the weather does and see whether we take our chance.

"She obviously handles very soft ground at the minimum trip, so she will appreciate every bit of rain that falls.

"She should still be improving, she’s done very little wrong in her career. She’s only ever lost on her racecourse debut and in a couple of Grade Ones.

"Constitution Hill looks an absolute superstar, State Man couldn’t live with him and he’s a multiple Grade One winner, a superstar in his own right. It doesn’t look like he can be beaten but it’s the age-old thing, never be afraid of one horse.

"We’re living the dream at the moment and we’ll see how the week pans out and cross each bridge as it comes."

Sandy Thomson’s Benson and Iain Jardine’s Voix Du Reve are the only other possibles, although the latter fails to meet the minimum requirement of a rating of 130 needed to run in a Grade One.

Shishkin is one of 17 entries in the Rehearsal Chase over almost three miles, a contest won 12 months ago by Venetia Williams’ L’Homme Presse.

When asked on Sunday if the race was an option for Shishkin, Henderson replied: "That is under consideration, as you can imagine. We’re going there anyway (with Constitution Hill)."

The trainer deems the Peterborough Chase on December 10 too close to his King George target on Boxing Day.

Shishkin is rated 173 so would be giving lumps of weight away to his rivals should he run, with the next highest rated being Snowden’s Datsalrightgino on 148, while that trainer has also entered Ga Law.

"It would certainly help if Shishkin runs, as it would keep the weight down for the others," said Snowden.

"They are both in the Coral Gold Cup as well. That was actually the plan but I thought I’d see what was in the Rehearsal and it could work to our advantage at the end of the day."